mRNA Transcript Diversity Creates New Opportunities for Pharmacological Intervention
نویسندگان
چکیده
منابع مشابه
mRNA transcript diversity creates new opportunities for pharmacological intervention.
Most protein coding genes generate multiple RNA transcripts through alternative splicing, variable 3' and 5'UTRs, and RNA editing. Although drug design typically targets the main transcript, alternative transcripts can have profound physiological effects, encoding proteins with distinct functions or regulatory properties. Formation of these alternative transcripts is tissue-selective and contex...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2012
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.111.076604